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Pocock sequential testing4/20/2023 ![]() ![]() By leveraging development, we discovered somatic topography among nose-up and nose-down projection neuron subtypes. More broadly, our data suggest that, like invertebrates, temporal mechanisms may assemble vertebrate sensorimotor architecture. The spatial and temporal attributes we uncover constrain the developmental mechanisms that may specify the fate, function, and organization of vestibulo-ocular reflex neurons. Collectively, we find that development reveals previously hidden organization to the input, processing, and output layers of a highly conserved vertebrate sensorimotor circuit. Finally, birthdate revealed spatial patterns of axonal arborization and synapse formation to projection neuron outputs. Next, with electron microscopy and loss-of-function assays, we found that patterns of peripheral innervation to projection neurons were similarly organized by birthdate. We first discovered that both somatic position and stimulus selectivity follow projection neuron birthdate. By measuring activity in birthdated neurons, we revealed a functional map within the central vestibular projection nucleus that stabilizes gaze in the larval zebrafish. Oddly, vestibular (balance) nuclei are thought to be disorganized. This topography reflects developmental pressures. Across the nervous system, neurons with similar attributes are topographically organized. ![]()
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